Related Products of 773134-11-5,Some common heterocyclic compound, 773134-11-5, name is Methyl 4-bromo-2,6-difluorobenzoate, molecular formula is C8H5BrF2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of methyl 4-bromo-2,6-difluorobenzoate (22.5 g, 90 mmol) in N,N- dimethylformamide (100 mL) was added (2,4-dimethoxyphenyl)methanamine (16.49 g, 99 mmol) and K2C03 (18.58 g, 134 mmol) and the mixture was heated to 100 C and stirred overnight. The mixture was added to 50 mL water, extracted with ethyl acetate (30 mL x 3), dried over Na2S04 and evaporated to afford a brown oil. The oil was purified by column chromatography on silica gel (ethyl acetate/petroleum ether = 0 – 10%) affording methyl 4-bromo-2-((2,4-dimethoxybenzyl)amino)-6-fluorobenzoate (20 g, 45.2 mmol, 50 % yield) as a yellow solid. NMR (400 Hz, DMSO-d6 ) delta: ppm 7.85 (t, 1 H, J = 4.4 Hz), 7.16 (d, 1 H, J = 6.4 Hz), 6.755 (s, 1 H), 6.66 (d, 1 H, J = 8.8Hz), 6.60 (m, 1 H), 3.83 (s, 3 H), 3.81 (s, 3H), 4.13-3.94 (m, 3H), 3.48-3.50 (m, 1 H), 3.74 (s, 3H)
The synthetic route of 773134-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; JIN, Qi; POHLHAUS, Denise Teotico; SPLETSTOSER, Jared; (320 pag.)WO2017/98440; (2017); A1;,
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