Month: August 2021

Application of 61644-18-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61644-18-6, name is Chloromethyl isobutyrate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of (S)-1 -(((3-cyanopyridin-2-yl)oxy)methyl)-4- ((1 R,3aS,5aR,5bR,7aR,1 1 aS,1 1 bR,13aR,13bR)-3a-((2-((1 s,4R)-1 -hydroxy-4- (methylsulfonyl)cyclohexyl)ethyl)amino)-5a,5b,8,8, 1 1 a-pentamethyl-1 -(prop-1 -en-2-yl)- 2,3,3a,4,5,5a,5b,6,7,7a,8,1 1 ,1 1 a,1 1 b,12,13,13a,13b-octadecahydro-1 H- cyclopenta[a]chrysen-9-yl)cyclohex-3-ene-1 -carboxylic acid (200 mg, 0.230 mmol) and chloromethyl isobutyrate (62.8 mg, 0.460 mmol) in DMF (5.0 ml_) were added potassium carbonate (159 mg, 1 .149 mmol) followed by sodium iodide (6.89 mg, 0.046 mmol) at 0 C under Nitrogen atmosphere. The reaction mixture was allowed to warm to 27 C and stirred for 16 hr. The progress of the reaction was monitored by TLC (Si02, 5% MeOH/DCM, Rf = 0.4, KMn04-active). The reaction mixture was quenched with ice water (50 ml_) and extracted with EtOAc (2 c 30 ml_). The combined organic layers were washed with brine (50 ml_), dried over Na2S04, filtered and concentrated under reduced pressure to give the crude residue as sticky oil. The crude compound was triturated with chilled n-pentane (3 x 10 ml_) filtered and dried under high vacuum to afford (isobutyryloxy)methyl (S)-1 -(((3-cyanopyridin-2-yl)oxy)methyl)-4- ((1 R,3aS,5aR,5bR,7aR,1 1 aS,1 1 bR,13aR,13bR)-3a-((2-((1 s,4R)-1 -hydroxy-4- (methylsulfonyl)cyclohexyl)ethyl)amino)-5a,5b,8,8, 1 1 a-pentamethyl-1 -(prop-1 -en-2-yl)- 2,3,3a,4,5,5a,5b,6,7,7a,8,1 1 ,1 1 a,1 1 b,12,13,13a,13b-octadecahydro-1 H- cyclopenta[a]chrysen-9-yl)cyclohex-3-ene-1 -carboxylate (93 mg, Yield: 40%, white solid. NMR (400 MHz, CDCI3) d = 8.32 (dd, J = 2.0, 5.0 Hz, 1 H), 7.86 (dd, J = 2.0, 7.5 Hz, 1 H), 6.98 (dd, J = 5.0, 7.6 Hz, 1 H), 5.81-5.77 (m, 2H), 5.36-5.33 (m, 1 H), 5.19-5.17 (m, 1 H), 4.74-4.71 (m, 1 H), 4.61 -4.55 (m, 3H), 2.84-2.64 (m, 7H), 2.57-2.50 (m, 1 H), 2.25- 1 .82 (m, 12H), 1 .72-1 .38 (m, 22H), 1 .32-1 .22 (m, 6H), 1 .13 (d, J = 7.0 Hz, 6H), 1 .07-1 .01 (m, 6H), 0.98-0.94 (m, 6H), 0.93-0.88 (m, 3H), 0.86-0.82 (m, 3H). LCMS: RT = 7.1 1 mins, (M+H) = 970.4, Purity = 97%, HPLC Purity = 96%, Chiral HPLC Purity = 94%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Chloromethyl isobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; (61 pag.)WO2019/207460; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 17100-65-1,Some common heterocyclic compound, 17100-65-1, name is Methyl 2-bromo-4-methoxybenzoate, molecular formula is C9H9BrO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

10280] Synthesis of methyl 2-(6-tert-butyl-9H-pyrido[2,3- b]indol-9-yl)-4-methoxybenzoate: A mixture of 7-tert-butyl- 9H-pyrido[2,3-b]indole (3.07 g, 13.68 mmol, 1.0 eq), methyl 2-methyl 2-bromo-4-methoxybenzoate (5.03 g, 20.52 mmol, 1.5 eq), Cul (0.13 g, 0.68 mmol, 0.05 eq), K2C03 (3.97 g, 28.73 mmol, 2.1 eq), trans-N?,N2-dimeth- ylcyclohexane-1,2-diamine (0.39 g, 2.74 mmol, 0.2 eq) in DMSO (35 mE) was stirred at a temperature of 105-115 C.for 4 days under a nitrogen atmosphere and then cooled to ambient temperature. The mixture was diluted with ethyl acetate and filtered. The filtrate was washed with water three times, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified through column chromatography on silica gel using hexane/ ethyl acetate (10:1-5:1-3:1) as eluent to obtain the desired product as a yellow solid 3.52 g in 66% yield. ?H NMR (DMSO-d5, 400 MHz): oe 1.44 (s, 9H), 3.21 (s, 3H), 3.91 (s, 3H), 7.23-7.29 (m, 4H), 7.57 (dd, J=8.8, 2.0 Hz, 1H), 8.06 (d, J=9.2 Hz, 1H), 8.3 1-8.32 (m, 2H), 8.65 (d, J=8.0, 1.6 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-bromo-4-methoxybenzoate, its application will become more common.

Reference:
Patent; Arizona Board of Regents on behalf of Arizona State University; Li, Jian; Li, Guijie; (424 pag.)US2016/359125; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 84228-44-4, The chemical industry reduces the impact on the environment during synthesis 84228-44-4, name is Methyl 4-amino-3-chlorobenzoate, I believe this compound will play a more active role in future production and life.

Sodium triacetoxyborohydride (3.47 g, 16.39 mmol) was added to a solution of methyl 4-amino-3-chlorobenzoate (1.014 g, 5.46 mmol), cyclopropanecarboxaldehyde (0.816 mL, 10.93 mmol), and acetic acid (1.876 mL, 32.78 mmol) in CH2Cl2 (40 mL). The reaction mixture was stirred at room temperature under nitrogen for 24 h. After concentration, the product was taken up with EtOAc (100 mL), washed with saturated NaHCO3 (3*20 mL), NaCl (20 mL) and dried over Na2SO4. The crude product was purified by MPLC on silica gel using Hex/EtOAc (4:1) to give 1.154 g (88%) of a colorless oil. 1H NMR (400 MHz, CHLOROFORM-D) delta 0.27-0.32 (m, 2H), 0.59-0.65 (m, 2H), 1.09-1.21 (m, 1H), 3.07 (dd, J=7.03, 5.08 Hz, 2H), 3.86 (s, 3H), 4.82-4.95 (m, 1H), 6.59 (d, J=8.59 Hz, 1H), 7.82 (dd, J=8.59, 1.95 Hz, 1H), 7.95 (d, J=1.95 Hz, 1H); MS (ESI) (M+H)+: 240.13.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-3-chlorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; US2009/62251; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1128-00-3, name is Ethyl 2-aminocyclohex-1-enecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1128-00-3, Recommanded Product: Ethyl 2-aminocyclohex-1-enecarboxylate

To the intermediate alpha-methylacid bromothiazole above (197 mg, Compound 52 in Scheme 11) in dichloromethane (10 mL) was added one drop of DMF, and then a solution of oxalyl chloride (1.6 mL, 2 N in dichloromethane). The mixture was warmed to room temperature and stirred for 1 h. The resulting mixture was concentrated in vacuo and then dissolved in dichloromethane (10 mL). To the resulting solution was then added the common 2-aminocyclohex-1-ene-1-carboxylate ester (400 mg). The resulting mixture was stirred overnight. The crude material was purified by Biotage (5-10% ethyl acetate in hexane) to give the amide as a colorless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-aminocyclohex-1-enecarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Raghavan, Subharekha; Colletti, Steven L.; Ding, Fa-Xiang; Shen, Hong; Tata, James R.; Lins, Ashley Rouse; Smenton, Abigail Lee; Chen, Weichun; Schmidt, Darby Rye; Tria, George Scott; US2006/293364; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35180-01-9, name is Chloromethyl isopropyl carbonate, A new synthetic method of this compound is introduced below., Product Details of 35180-01-9

Step 1: Iodomethyl Isopropyl Carbonate (49B) Chloromethyl isopropyl carbonate (49A) (30.0 g, 0.198 mol) was dissolved in acetone (150 mL), sodium iodide (60.0 g, 0.396 mol) was added to the mixture, stirring at 30 C. for 4 h. The mixture was then filtered and concentrated in vacuo, the residue was purified by silica gel column chromatography (petroleum ether) to afford iodomethyl isopropyl carbonate (49B) as a light yellow liquid (40.4 g, yield: 83.7%). 1H NMR (400 MHz, CDCl3): delta 5.93 (s, 1H), 4.97-4.91 (m, 1H), 1.32 (d, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sichuan Haisco Pharmaceutical Co., Ltd.; QIN, Linlin; LI, Fangqiong; YI, Shixu; LUO, Huadong; LUO, Xinfeng; WAN, Songlin; REN, Lei; LIU, Guoliang; WEI, Yonggang; LIU, Jianyu; TANG, Peng Cho; (121 pag.)US2016/60197; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 2969-81-5, name is Ethyl 4-bromobutyrate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2969-81-5, HPLC of Formula: C6H11BrO2

A mixture of 4-chlorophenol (10 g, 78 mmol) and ethyl 4-bromobutanoate (22.8 g, 117 mmol) in ethanol (100 mL) with K2CO3 (16.1 g, 1 17 mmol) was refluxed for 12 hours. The reaction mixture was cooled and filtered. The filtrate was concentrated under reduced pressure. To the residue was added ethyl acetate (100 mL) and 0 (70 mL). The two phases were separated, and the aqueous phase was extracted with ethyl acetate (3 x 40 mL). The combined organic phases were combined, dried over anhydrous Na2SO/t, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (Si(, petroleum ether:ethyl acetate = 100: 1 to 5: 1) to give the title compound (10 g, 39.1 mmol, 50% yield).JH NMR (400MHz, DMSO- ) delta ppm = 7.33 – 7.27 (m, 2H), 6.96 – 6.90 (m, 2H), 4.06 (q, J=7.1 Hz, 2H), 3.97 (t, J=6.3 Hz, 2H), 2.44 (t, J=7.3 Hz, 2H), 1.95 (quin, J=6.8 Hz, 2H), 1.17 (t, J=7.1 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina, A.; FROST, Jennifer, M.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; XIONG, Zhaoming; SWEIS, Ramzi, Farah; DART, Michael, J.; BROWN, Brian, S.; MURAUSKI, Kathleen; (673 pag.)WO2019/90069; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 383-62-0, These common heterocyclic compound, 383-62-0, name is Ethyl 2-chloro-2,2-difluoroacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Weigh 2.68g (20mmol) of 4-methyl acetophenone and 13.4ml methyl tert-butyl ether (MTBE), into the reaction flask and stir, 3.70g (23.3mmol) of ethyl difluorochloroacetate was added,A 25% sodium methylate (24 mmol) solution in methanol was added dropwise at room temperature, and the mixture was heated to 45-55 C. during the dropwise addition and stirred for 24 hours.After the reaction was completed, the solvent was concentrated under reduced pressure to give a light yellow solid, which was stirred with 10% diluted hydrochloric acid (v / v) and extracted twice with ethyl acetate. The ethyl acetate layer solution into the reaction flask, add appropriate amount of ethyl acetate and water and stir, add 4.47g (20mmol) p-sulfonamidophenylhydrazine hydrochloride, warmed to 75-85 C, the reaction was stirred for 2 hours, the reaction Completed, room temperature cooling crystallization. Filtration, cake drying 60 C, 60% ethanol (m / m) that was recrystallized, HPLC purity of 99%.

The synthetic route of 383-62-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Chen Yuqing; Liu Qiang; Liu Yongping; Wang En; (13 pag.)CN104418804; (2017); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 37746-78-4, A common heterocyclic compound, 37746-78-4, name is (E)-Ethyl 4-bromobut-2-enoate, molecular formula is C6H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 10-L 4-necked round-bottom flask was placed 2-bromo-4-fluorophenol (500 g, 2.62 mol, 1.00 equiv), N,N-dimethylformamide (5 L), potassium carbonate (1253 g, 9.07 mol, 3.46 equiv), and ethyl (2E)-4-bromobut-2-enoate (1010 g, 5.23 mol, 2.00 equiv). The resulting solution was stirred for 12 h at room temperature. The solids were collected by filtration. The reaction was then quenched by the addition of 15 L of water and extracted with 3×10 L of ethyl acetate. The organic layers were combined and washed with 4×20 L of brine. The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1/20). The collected fractions were combined and concentrated under vacuum to give 500 g (63%) of ethyl (2E)-4-(2-bromo-4-fluorophenoxy)but-2-enoate (5) as a white solid.

The synthetic route of 37746-78-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTUATE THERAPEUTICS INC.; ZHANG, Yamin; (32 pag.)WO2019/79299; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 7149-03-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7149-03-3, name is Ethyl 4-amino-3-bromobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(4-cyanophenyl)zinc pivalate (lg) reacts well with different aromatic andheteroaroamatic bromides and the corresponding cross-coupling products are obtained in 56- 88 % yield (entries 11-13).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-amino-3-bromobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUDWIG-MAXIMILIANS-UNIVERSITAeT MUeNCHEN; KNOCHEL, Paul; BERNHARDT, Sebastian; MANOLIKAKES, Georg; WO2012/85168; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 1186-73-8, name is Trimethyl methanetricarboxylate, molecular formula is C8H12O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1186-73-8

Embodiment 2; A. Synthesis of (3aS,4S,6aR)-1,3-dibenzyl-4-(omega,omega,omega-3-methoxycarbonyl butyl)-4H-1H-thiophene[3,4-d]iminazole-2,4(1H)- ketone; Put 300 ml methylbenzene and 60% sodium hydride 3.3 g (0.0825 mol) into the 500 ml four-neck flask with reflux condenser pipe, dropping pipette, stirrer and thermometric instrument which is protected by dry nitrogen; and then add 15.8 g (0.083 mol) methane tricarboxylic acid triethyl ester into the flask at the temperature of below 80 C. and protected for 2 h by heat preservation; add 33.3 g (0.075 mol) bromine sulfonium salts into the flask and then raise the temperature and control the temperature of the entire flask at 80 C. for a 15 h reaction; cool it to the normal temperature and use 5% sulfuric acid to adjust the pH to pH=3; separate the organic layer and extract the water layer by 100 ml methylbenzene for two times; use 40 ml 5% sodium bicarbonate water solution wash the organic layer for two times; dry the oil layer by anhydrous sodium sulfate, filtrate and reduce pressure to recycle faint yellow fluid, finally get the target object-0.2 g tri-ester dibenzyl biotin (95.3% of the theoretical value), and the HPLC measured content is 98.0% with no impurity 5 (hereinafter to be referred as dicarboxylic ester).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1186-73-8, its application will become more common.

Reference:
Patent; Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical Factory; US2012/65406; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics