Electric Literature of 816-27-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 816-27-3, name is Ethyl 2-ethoxy-2-iminoacetate, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 3-aminopyridine-4-sulfonamide (112) (500 mg, 2.89 mmol), ethyl 2-ethoxy-2- iminoacetate (629 mg, 4.34 mmol) and DBU (879 mg, 5.78 mmol) in EtOH (10 mL) was heated in a microwave at 135 C for 30 min then allowed to cool to r.t.. The mixture was concentrated and the residue was dissolved in water, acidified to pH 2 with 1 M aqueous HCI and extracted with EtOAc. The organic layer was washed with water and brine, dried over Na2S04, filtered, concentrated and the residue was purified by preparative TLC (MeOH/DCM = 1 :20) to give the product (50 mg, 7% yield) as a yellow solid. LCMS (ES- API): Rt 0.51 min; m/z 255.9 [M+H] +. 1 H NMR (400 MHz, d6-DMSO) delta 13.2 (brs, 1H), 9.09 (s, 1H), 8.81 (d, J = 5.2 Hz, 1H), 7.88 (d, J =5.2 Hz, 1H), 4.42 (t, J = 7.2 Hz, 2H), 1.37 (t, J = 7.2 Hz, 3H).
The chemical industry reduces the impact on the environment during synthesis Ethyl 2-ethoxy-2-iminoacetate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CTXT PTY LIMITED; MORROW, Benjamin Joseph; FOITZIK, Richard Charles; CAMERINO, Michelle Ang; LAGIAKOS, Helen Rachel; WALKER, Scott Raymond; BOZIKIS, Ylva Elisabet Bergman; STEVENSON, Graeme Irvine; CUZZUPE, Anthony Nicholas; STUPPLE, Paul Anthony; (313 pag.)WO2019/43139; (2019); A1;,
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