Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Ethyl (E)-3-Ethoxyacrylate
To a mixture of 19 (3.7 g, 21.9 mmol) and (E)-ethyl 3-ethoxyacrylate (4.7 g, 32.8 mmol) in DMF (76 mL) was added Cs2CO3 (10.7 g, 32.8 mmol) and the reaction was heated at 110 C for 15 hours. After cooling to ambient temperature, the solvent was removed in vacuo and the residue was washed with acetic acid to pH 4 and extracted with EA (100 ml) for three times. The extract was dried over Na2SO4. The crude product was purified by flash chromatography to afford the title compound (2.2 g, 45.9 %). 1H NMR (400 MHz, CDCl3) delta 9.56 (br, 1H), 8.01 (d, J = 8.0 Hz, 1H), 6.08 (d, J = 8.0 Hz, 1H), 4.37 (q, J = 7.2 Hz, 2H), 2.50 (s, 1H), 1.39 (t, J = 7.2 Hz, 3H). MS (ESI) m/z 222 [M+H]+.
According to the analysis of related databases, 5941-55-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Lu, Xiaoyun; Tang, Jian; Liu, Zhiyong; Li, Minke; Zhang, Tianyu; Zhang, Xiantao; Ding, Ke; Bioorganic and Medicinal Chemistry Letters; vol. 26; 24; (2016); p. 5916 – 5919;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics