Reference of 85953-29-3,Some common heterocyclic compound, 85953-29-3, name is Methyl 2-chloro-4-fluorobenzoate, molecular formula is C8H6ClFO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
20.85 g of methyl 2-chloro-4-fluorobenzoate were dissolved in 150 ml of N-methylpyrrolidone, 30.68 g of potassium carbonate and 9.38 ml of 3-methylpyrazole were added thereto, and the mixture was stirred at 120 C for 3 hours.. Additionally, thereto was added 1.79 ml of 3-methylpyrazole, and the mixture was stirred at 120 C for 3 hours.. The reaction solution was cooled, mixed with water, and extracted with EtOAc. The organic layer was washed with water and brine, and then dried over magnesium sulfate.. The solvent was evaporated, and then the residue was purified by silica gel column chromatography (hexane-EtOAc (20:1)) to obtain 9.25 g of methyl 2-chloro-4-(3-metyl-1H-pyrazol-1-yl)benzoate.
The synthetic route of 85953-29-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1445253; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics