Sources of common compounds:

Some common heterocyclic compound, 4630-82-4, name is Methyl cyclohexanecarboxylate, molecular formula is C8H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Methyl cyclohexanecarboxylate

Example 5OA ; methyl 1 -(prop-2-ynyl)cyclohexanecarboxylateTo a solution of diisopropylamine (879 muL, 6.22 mmol) in anhydrous tetrahydrofuran (12 mL) at – 4O0C under nitrogen was added 1.6 M n-butyl lithium in hexane (3.9 mL, 6.22 mmol), followed by hexamethylphosphoramide (4 mL). The mixture was cooled down to – 780C and added a solution of methyl cyclohexanecarboxylate (80 7muL, 5.65 mmol) in tetrahydrofuran (4 mL) with the temperature maintained below -7O0C throughout the addition. After 15 min, propargyl bromide (80% w/w in xylene, 2.5 mL, 22.6 mmol) was added, and the reaction mixture was allowed to warm to room temperature. After 30 min, it was quenched with saturated ammonium chloride, and extracted with ethyl acetate. The organic phase was washed with water (x 4), dried over MgSO4, filtered and concentrated to get 900 mg the title intermediate as a pale brown oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4630-82-4, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; WO2008/134690; (2008); A1;,
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Ester – an overview | ScienceDirect Topics