At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-bromo-2-methylbenzoate, and friends who are interested can also refer to it.
Synthetic Route of 99548-55-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99548-55-7 name is Methyl 4-bromo-2-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation 35: 2-Methyl-4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)benzoic acid methyl ester 4-Bromo-2-methylbenzoic acid methyl ester (0.028 mmol), 4,4,5, 5,4′,4′,5′,5′- octamethyl-[2,2′]bi[[l,3,2]dioxaborolanyl] (0.028 mmol) and potassium acetate (0.064 mmol) were combined in dioxane (65 mL) and de-gassed with argon. [l,l’-bis(diphenylphosphino)- ferrocene]dichloropalladium (5.62xlO~4 mmol) and l,l’-bis(diphenylphosphino)ferrocene (5.62xlO~4 mmol) were added and the mixture stirred at 950C under argon for 16 h. The mixture was cooled then partitioned between water and ethyl acetate. The water was separated and washed with ethyl acetate. The organic extracts were combined, dried over MgSO4, concentrated and purified by dry-flash chromatography to afford the title compound: RT = 4.07 min; m/z (ES+)=277.24 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-bromo-2-methylbenzoate, and friends who are interested can also refer to it.
Reference:
Patent; PROSIDION LIMITED; WO2009/50522; (2009); A1;,
Ester – Wikipedia,
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