Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 680217-71-4, name is Ethyl 2-(2,6-difluorophenyl)acetate, A new synthetic method of this compound is introduced below., Product Details of 680217-71-4
As in the scheme, a solution of scheme 28 compound 1 (1 g, 3.95 mmol), ester (1.47 g, 7.9 mmol) and CS2CO3 (3.86 g, 11.85 mmol) in DMF (30 mL) under N2 was added and stirred at 110 C for 4 h. The solvent then was evaporated and the remaining residue was diluted with water and extracted with CH2C12. The combined extracts were washed with brine, dried over Na2S04 and concentrated in vacuo. The crude product was purified by prep-HPLC to afford scheme 28 compound 2 (420 mg, 27.4%) as a brown solid.
The synthetic route of 680217-71-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
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