Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 431-47-0, name is Methyl 2,2,2-trifluoroacetate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2,2,2-trifluoroacetate
According to the procedure for 5d, 4-bromo-1-(pentan-3-yl)-1H-pyrazole (1.23 g, 5.68 mmol) was dissolvedin dry THF (15 mL) at -78 C under nitrogen and was stirred for 10 min. n-BuLi (2.5 M inhexanes, 2.38 mL, 5.96 mmol) was added drop wise to the solution was stirred for 2 hours at -78 C. After two hours, methyl trifluoroacetate (0.68 mL, 6.81 mmol) was added drop wise andstirred for 30 min at -78 C. The solution was then allowed to warm up to room temperature andlet stir for overnight. The mixture was then quenched with NH4Cl (20 mL) and extracted withether (50 mL), and dried over MgSO4. After concentration in vacuo (note: remove shortly afterthe ether is removed, because the compound is quite volatile), the residue was purified with flash chromatography over silica gel (DCM: hexane = 20:80) to yield the product as a liquid in 67%yield (0.90 g).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Camerino, Eugene; Wong, Dawn M.; Tong, Fan; Koerber, Florian; Gross, Aaron D.; Islam, Rafique; Viayna, Elisabet; Mutunga, James M.; Li, Jianyong; Totrov, Maxim M.; Bloomquist, Jeffrey R.; Carlier, Paul R.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 20; (2015); p. 4405 – 4411;,
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