27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C9H11NO3
Description 20: Methyl 4-{[(2-fluorophenyl)carbonyl]amino}-2-(methyloxy)benzoate; Methyl 4-amino-2-(methyloxy)benzoate (10.0 g, 55.2 mmol) was suspended in dichloromethane (50 ml_), cooled in an ice bath and treated dropwise with diisopropylethylamine (10.57 ml_, 60.8 mmol) followed by 2-fluorobenzoyl chloride (7.25 ml_, 60.8 mmol). The mixture was allowed to warm to room temperature and stirred under argon for 2.5 hours. The solvent was evaporated under reduced pressure. The residue was taken up in ethyl acetate, washed with saturated aqueous sodium bicarbonate and brine. The ethyl acetate layer was separated. A solid came out of solution upon standing. This was collected by filtration to give the title compound. LC/MS (ES+ve): [M+H]+ at m/z 304 (C16H14FNO4 requires [M+H]+ at m/z 304).
The synthetic route of 27492-84-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2007/138033; (2007); A1;,
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