In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64123-77-9 as follows. name: Methyl 2-(3-fluorophenyl)acetate
Methyl 2-(3-fluorophenyl)acetate (1.90 g, 1 1.3 mmol) and N-bromo succinimide (2.01 g, 1 1.3 mmol) were dissolved in CC14 (80 ml). HBr (64 ul,0.56 mmol) was added and the mixture was stirred under reflux overnight. The mixture was cooled at room temperature, diluted with DCM and washed with sat. NaHCO3, water and brine. The organic layer was dried (Na2SO4), filtered and evaporated obtaining intermediate 115 (2.68 g, 96% yield).
According to the analysis of related databases, 64123-77-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; AMARI, Gabriele; RICCABONI, Mauro; WO2011/160919; (2011); A1;,
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