Application of 20921-00-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20921-00-0 as follows.
To a mixture of compound 6B (3.41 g, 14.956mmol) in THF at 0 was added CH3MgBr (32.9 mmol) . The mixture was allowed to stir at 020 for 16 hours, and then the mixture was quenched with NH4Cl, and extracted with ethyl acetate. The organic extract was washed with H2O and brine, dried over Na2SO4, filtered and concentrated in vacuo. Tthe residue obtained was purified using flash column chromatography (petroleum ether: ethyl acetate 20: 15: 1) to provide compound 6C.
According to the analysis of related databases, 20921-00-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; YU, Wensheng; KOZLOWSKI, Joseph A.; TONG, Ling; COBURN, Craig A.; HU, Bin; ZHONG, Bin; HAO, Jinglai; WANG, Dahai; (101 pag.)WO2018/32467; (2018); A1;,
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