Electric Literature of 89-91-8,Some common heterocyclic compound, 89-91-8, name is Methyl 2,2-dimethoxyacetate, molecular formula is C5H10O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
j00399j A mixture of(3,4-difluorophenyl) methanamine (2.0 g, 14 mmol) and methyl 2,2- dimethoxyacetate (3.8 g, 28 mmol) was stirred at 140 C for 1 hour in the microwave. On completion, the reaction mixture was diluted with dichloromethane (20 mL) and concentrated in vacuo to give cmde compound B-64 (4.3 g, crude) as a yellow solid. LCMS (E): tR=0.596 mi, (ES) mlz (M+H) =246.1.
The synthetic route of 89-91-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
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