Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2557-13-3, name is Methyl 3-(trifluoromethyl)benzoate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-(trifluoromethyl)benzoate
3-trifluoromethyl-benzoic acid methyl ester fluoride to 4.30g (21.1mmol)Cesium 92.6mg the (0.696mmol) added under an argon atmosphere, then cooled to -10 or less of. This trifluoromethyl trimethylsilane about 4mL (about 27mmol) was added dropwise at -10 or less. 1 hour at -10 C., further stirred for 1 hour at room temperature. Then extracted by the addition of methylene chloride and water to the reaction solution. The organic phase is dried over magnesium sulfate, and then concentrated. The residue was purified by silica gel column chromatography (developing solvent = n-hexane / ethyl acetate = 98/2 [volume]). Concentration collect a portion corresponding to Rf value of about 0.9, as a colorless transparent liquid trimethyl (2,2,2-trifluoro-1-methoxy-1- (3- (trifluoromethyl) phenyl) ethoxy) silane 4.46g (65%) obtained. Incidentally, Rf is selected from the group consisting of the ratio of distance traveled from the origin with respect to the distance from the origin to the solvent front of the sample of interest (relative moving distance).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NIPPON SODA COMAPNY LIMITED; ITO, YOSHIKAZ; KUBOTA, YASUSHI; ICHINARI, DAISUKE; INOUE, HIROKI; IWATA, JYUN; NAKASHIMA, RYOYO; KURUSHIMA, HIROAKI; MATSUDA, KEIICHIRO; KUTOSE, KOICHI; (90 pag.)JP5653442; (2015); B2;,
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