Synthetic Route of 455-68-5, The chemical industry reduces the impact on the environment during synthesis 455-68-5, name is Methyl 3-fluorobenzoate, I believe this compound will play a more active role in future production and life.
EXAMPLE 2 72.4 parts of methyl 3-fluorobenzoate are dissolved in 300 parts of 100percent strength sulfuric acid with stirring at not more than 30° C., the solution is cooled to 0°-10° C. and then, over the course of 2 hours, a mixture of 32.7 parts of 98percent strength nitric acid and 78.3 parts of 100percent strength sulfuric acid is added dropwise with continuous cooling at 0°-10° C., and the mixture is stirred without cooling for 3 hours, during which the temperature of the nitrating mixture rises to 20° C. Then 175 parts of water are added dropwise, again with continuous cooling. The methyl fluoronitrobenzoate separates out as an oil which is separated off, washed until neutral in portions with 350 parts of water, and dried in vacuo at 100° C. 92 parts of methyl fluoronitrobenzoate are obtained, comprising 98.1percent methyl 5-fluoro-2-nitrobenzoate and 1.9percent methyl 3-fluoro-2-nitrobenzoate, with an s.p. of 34.0° C. and a purity (GC) of >99percent based on isomer mixture.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-fluorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hoechst Aktiengesellschaft; US5543550; (1996); A;,
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