Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4891-38-7, name is Methyl Phenylpropiolate, A new synthetic method of this compound is introduced below., COA of Formula: C10H8O2
General procedure: Steroidal/nonsteroidal bromo vinyl aldehyde (0.5 mmol), alkyne (0.5 mmol), benzyl amine (0.5 mmol), Pd(OAc)2 (5 mol%), PPh3 (10 mol%), Na2CO3 (1.5 mmol) and neutral alumina (200 mg) were mixed intimately and the mixture was irradiated in a closed vessel in a Synthos 3000 microwave reactor at 600 Watt (140 C and 12 bar) for 10 min. After 10 min ethylacetate (30 mL) was added to the reaction mixture and it was filtered through whatman filter paper. The residue obtained after removal of ethylacetate layer was purified by silica gel column chromatography using EtOAc/hexane as the eluent to afford the pyridine derivative. The alumina on the filter paper was then dried in vacuo and can be used again for another two times in place of Pd(OAc)2 without substantial loss of the yield of the product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Shekarrao, Kommuri; Nath, Dipankar; Kaishap, Partha Pratim; Gogoi, Sanjib; Boruah, Romesh C.; Steroids; vol. 78; 11; (2013); p. 1126 – 1133;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics