Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3697-68-5, name is Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate
Preparation of intermediate 5B:l-(((5-bromopyrimidin-2-yl)oxy)methyl)cyclopropane carboxylic acid ethyl ester5-Bromo-2-hydroxypyrimidine (850 mg, 4.86 mmol) and triphenylphosphine (1.91 g, 7.3 mmol) were dissolved in THF, to which was added diisopropyl azodicarboxylate DIAL) (1.19 mL, 6 mmol). The reaction solution was stirred at room temperature for 1 h, after which was added l-(hydroxymethyl)cyclopropanecarboxylic acid ethyl ester 5A (700 mg, 4.86 mmol). The reaction proceeded overnight at room temperature under stirring. The solvents were evaporated and the residue was purified with a silica gel column (n-hexane: ethyl acetate = 20: 1) to give 580 mg of white solid 5B. Yield: 39.7%.MS (ESI, m/z): [M+H]+: 300.9; 1H-NMR (300 MHz, CDC13): 8.55 (s, 2H), 4.53 (s, 2H), 4.16 (q, 2H, J= 7.2 Hz), 1.41(dd, 2H, J = 4.2 Hz, J = 3.0 Hz), 1.23 (t, 3H, J= 7.2 Hz), 1.06 (dd, 2H, J = 4.2 Hz, J= 3.0 Hz).
According to the analysis of related databases, 3697-68-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BEIJING HANMI PHARMACEUTICAL CO., LTD; ZHANG, Bo; YANG, Jun; LIU, Jinming; HUANG, Hai; WU, Yong; TAO, Ran; XU, Jiangcheng; SHEN, Ning; MOON, Sunghwan; KIM, Maengsup; WO2013/56679; (2013); A1;,
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