Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., name: Methyl 3-bromo-4-fluorobenzoate
Sodium hydride (0.88 g, 22 mmol, 60% w/w) was added to N,N (1r,4r)-4-methylcyclohexane-1-ol (0.84 g, 7.3 mmol) at 0 C – in dimethylformamide (30 mL) solution. The reaction solution was stirred at 0 C for 10 minutes. Then, methyl 3-bromo-4-fluorobenzoate (1.8 g, 8.2 mmol) was added, and the mixture was stirred at room temperature for 10 hours. The reaction was quenched with saturated ammonium chloride, ethyl acetate (50mL * 2), washed with saturated brine (20mL * 5) The organic phase was dried and evaporated to dryness to give a crude product. The crude product was subjected to column separation (petroleum ether: ethyl acetate = 20:1) to give a methyl group. 3-Bromo-4-(((1r,4r)-4-methylcyclohexyl)oxo)benzoate (1.2 g, yield 50%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 82702-31-6.
Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Ye Guozhong; Liu Lei; Bao Rudi; Wu Shenghua; Deng Haining; (130 pag.)CN110041253; (2019); A;,
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