Related Products of 40872-87-5, These common heterocyclic compound, 40872-87-5, name is Methyl 3-amino-4-chlorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
It heated and dried at 120 degrees C under decompression of a p-toluenesulfonic-acid monohydrate (25.6g) for 1 hour. The methyl 3-amino-4-chlorobenzoate (10g) and the propiononitrile (20 ml) were added there, and it heated at reflux for 16 hours. After cooling a reaction mixture radiationally, the saturated sodium bicarbonate aqueous solution (250 ml) was added, and it stirred for 10 minutes. Ethyl acetate extracted, after carrying out decompression distilling off of the propiononitrile (50mlx3). The organic layer was dried and concentrated in vacuum with anhydrous sodium sulfate. Silica gel column chromatography (developing solvent: petroleum ether/ethyl acetate) refined the obtained residue, and it obtained the mark compound (8.5g).
The synthetic route of 40872-87-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO DAINIPPON PHARMA COMPANY LIMITED; IKEDA, JUNYA; NAKAMURA, TAKANORI; OTAKA, HIROMICHI; (133 pag.)JP2016/28016; (2016); A;,
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