Some common heterocyclic compound, 20754-20-5, name is Methyl 3-(p-tolyl)acrylate, molecular formula is C11H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Methyl 3-(p-tolyl)acrylate
A method for constructing a quaternary carbon ring by visible light catalysis [2+2] reaction, comprising the following steps: The ruthenium complex 1 was used as a visible light catalyst, and 1.3 mg of the catalyst and 0.2 mmol were added to 2 mL of 1,4-dioxane.(E)-methyl-3-p-tolyl acrylate(corresponding R2 is p-tolyl and R3 is methoxy), wherein the concentration of the visible light catalyst is 1.0 x 10-3 M. Argon gas was introduced for ten minutes, and then light-illuminated in an argon atmosphere at 25 ° C for 36 hours with Blue LEDs of 450 nm ± 10 nm. After the reaction was completed, the mixture was directly dried and separated by column. Nuclear magnetic resonance, carbon, and mass spectrometry identify products as racemic(1R, 2R, 3S, 4S)-dimethyl-3,4-di-p-methylphenylcyclobutane-1,2-dicarboxylate. The conversion of the starting material was 100percent and the yield of the cyclobutane product was 90percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 20754-20-5, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Wu Lizhu; Lei Tao; Zhao Leimin; Zhou Chao; Liu Zan; Tong Zhenhe; (89 pag.)CN108623425; (2018); A;,
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