Adding a certain compound to certain chemical reactions, such as: 4934-99-0, name is Methyl 3-hydroxycyclobutanecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4934-99-0, Recommanded Product: 4934-99-0
To a solution of methyl 3-hydroxycyclobutanecarboxylate AA28 (19.7 g, 152 mmol) in dichloromethane (200 mL) was added pyridine (90.0 g, 1.14 mol) , 4-dimethylaminopyridine (5.60 g, 45.6 mmol) and tosyl chloride (58.0 g, 303 mmol) at room temperature. After stirred at room temperature overnight, the mixture was poured water (200 mL) and extracted with ethyl ester (200 mL) twice. The combined organic layers were washed with 0.5 M hydrochloride aqueous solution (200 mL) , saturated sodium bicarbonate aqueous solution (200 mL) , water (200 mL) and brine (200 mL) , dried over Na2SO4 (s), filtered and the filtrate was concentrated under reduced pressure at room temperature to afford the title compound (42.7 g, 99 %yield) as yellow oil.1H NMR (300 MHz, CDCl3) delta 7.77 -7.73 (m, 2H) , 7.34 -7.26 (m, 2H) , 4.77 -4.64 (m, 1H) , 3.66 -3.59 (m, 3H) , 2.67 -2.54 (m, 1H) , 2.50 -2.37 (m, 7H) .
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Reference:
Patent; JANSSEN SCIENCES IRELAND UNLIMITED COMPANY; JOHNSON & JOHNSON (CHINA) INVESTMENT LTD.; JIANG, Yimin; WAN, Zhao-Kui; CHEUNG, Wing Shun; LIU, Qian; DENG, Gang; LIANG, Chao; (230 pag.)WO2019/214610; (2019); A1;,
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