In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 88709-17-5 as follows. Recommanded Product: Ethyl 2-ethoxy-4-methylbenzoate
00465] Step 2: Synthesis of ethyl 4-(bromomethyl)-2-ethoxybenzoate: To a solution of ethyl 2-ethoxy-4-methylbenzoate (100 mg, 0.481 mmol) in 2 mL oftrifluoromethyl toluene was added NBS (94 mg, 0.529 mmol) and AIBN (10 mg) in portions. The mixture was heated to reflux and stirred for 24 h. The reaction mixture was concentrated, diluted with 10 mL of EA, washed with 5 mL of 4 N NaOH, 5 mL of brine, dried over anhydrous Na2S04 and concentrated under reduced pressure to afford ethyl 4-(bromomethyl)- 2-ethoxybenzoate as brown oil (42 mg, 30%), which was used for the next step directly.
According to the analysis of related databases, 88709-17-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; WO2011/38204; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics