Reference of 87808-49-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 1: Preparation of 2-(2-bromo-4-methylphenyl)propan-2-ol To a solution of methyl 2-bromo-4-methylbenzoate (4 g, 18 mmol) cooled at 0 C. was added methylmagnesium bromide (17.5 ml, 52.6 mmol) dropwise. The mixture was allowed to warm to rt and stirred overnight. Then it was quenched with aq. NH4Cl and extracted with ethyl acetate. The organic layer was dried over Na2SO4 and concentrated to provide the product (3.5 g, yield 85%). TLC analysis (silica gel plate, EA_PE=10%): Rf=0.5.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromo-4-methylbenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; AKAMA, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen; US2013/131017; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics