Some common heterocyclic compound, 1245643-11-1, name is Methyl 3,4-diamino-5-bromobenzoate, molecular formula is C8H9BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Methyl 3,4-diamino-5-bromobenzoate
At -40C, 2,2-dihydroxy-acetic acid (85.61 g; 93Ommol) in H20 (35 mL) was added dropwise to a solution of methyl-3,4-diamino-5-bromobenzoate (190 g; 775.28 mmol) in MeOH (2 L). Then, the reaction mixture was allowed to warm to rt and stirred for2h. The solid was filtered, washed with Et20 and dried under vacuum to give 214 g (98%) of a mixture of two intermediates la and lb (ratio 85/l5 by 1H NMR).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1245643-11-1, its application will become more common.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; ANGIBAUD, Patrick, Rene; QUEROLLE, Olivier, Alexis, Georges; BERTHELOT, Didier, Jean-Claude; MEYER, Christophe; WILLOT, Matthieu, Philippe, Victor; MEERPOEL, Lieven; (384 pag.)WO2017/60406; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics