Reference of 7686-78-4,Some common heterocyclic compound, 7686-78-4, name is Diethyl 2-vinylcyclopropane-1,1-dicarboxylate, molecular formula is C11H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The preparation method is:In an air atmosphere,Add 0.2 mmol of N-pyrimidindolline compound to the microwave reaction tube,0.4mmol of ethylene cyclopropane compound,0.003mmol of [Ru (p-cymene) Cl2] 2,0.04mmol are trimethylbenzoic acid,0.02mmol of silver hexafluoroantimonate, microwave reaction at 25 C for 2 hours;After completion of the reaction, rinse with ethyl acetate.Chromatographic separation after concentration under reduced pressure (silica gel 200-300 mesh, eluent: ethyl acetate / petroleum ether gradient elution, ratio from 0/100 to 100/0),Dried to a pale yellow oil,Yield: 70%, E / Z = 20: 1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diethyl 2-vinylcyclopropane-1,1-dicarboxylate, its application will become more common.
Reference:
Patent; Zhengzhou University; Henan Communication Polytechnic College; Zhu Xinju; Wang Qiuling; Xie Xiaona; Zhang Xiaojie; Yan Jing; Xu Yan; Hao Xinqi; Song Maoping; (15 pag.)CN110551106; (2019); A;,
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