Reference of 583-02-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-02-8, name is Ethyl 4-(trifluoromethyl)benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of 2,2,6,6-tetramethylpiperidine (TMPH, 1.5equiv) in THF (2mL/mmol of ester), a solution of n-butyllithium (1.45M in hexane, 1.5equiv) was added at -30C over 30min. After cooling at -78C, tris(isopropyl)borate (2.0equiv) was added over 20min. Ethyl benzoate or 4-(trifluoromethyl)benzoate or ethyl isonicotinate (1.0equiv) was added via syringe to the reaction mixture over 10min and the mixture was stirred at -78C for 3.5h. After warming to -30C, glacial acetic acid (1.5equiv) was added causing the internal temperature rising to -10C. Neopentyl glycol (1.5equiv) was added and the mixture was stirred at room temperature for 2h. Dichloromethane (20mL/mmol of ester) was then added. The organic phase was successively washed three times with satd aqueous NH4Cl, with satd aqueous NaHCO3 and with water, dried over MgSO4 and evaporated to give the desired compounds.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(trifluoromethyl)benzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fresneau, Nathalie; Cailly, Thomas; Fabis, Frederic; Bouillon, Jean-Philippe; Tetrahedron; vol. 69; 26; (2013); p. 5393 – 5400;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics