Adding a certain compound to certain chemical reactions, such as: 7686-78-4, name is Diethyl 2-vinylcyclopropane-1,1-dicarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7686-78-4, Product Details of 7686-78-4
Preparation method: In air atmosphere,Add 0.2 mmol of N-pyrimidindolline compound to the microwave reaction tube,0.24 mmol of ethylene cyclopropane compound,0.003 mmol of [Ru (p-cymene) Cl2] 2, 0.06 mmol of 1-adamantanic acid,0.04 mmol of silver hexafluoroantimonate,Microwave at 50 C for 2 hours;After completion of the reaction, rinse with ethyl acetate.Chromatographic separation after concentration under reduced pressure (silica gel 200-300 mesh, eluent: ethyl acetate / petroleum ether gradient elution, ratio from 0/100 to 100/0)Dried to a pale yellow oil,The yield was 76% and E / Z> 20: 1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl 2-vinylcyclopropane-1,1-dicarboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Zhengzhou University; Henan Communication Polytechnic College; Zhu Xinju; Wang Qiuling; Xie Xiaona; Zhang Xiaojie; Yan Jing; Xu Yan; Hao Xinqi; Song Maoping; (15 pag.)CN110551106; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics