Related Products of 35418-07-6, A common heterocyclic compound, 35418-07-6, name is Methyl 3-(4-aminophenyl)propanoate, molecular formula is C10H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE XXVII 1-[4-[2-(Methoxycarbonyl)ethyl]phenyl]-4,5-dimethyl-3H-imidazol-2-one 2.4 g of N-[4-[2-(methoxycarbonyl)ethyl]phenyl]-urea ?melting point: 152-154 C. (sintering from 145 C.); prepared from methyl 3-(4-aminophenyl)propionate by reacting with potassium cyanate in the presence of glacial acetic[acid]and 2.9 g of acetoin are heated to 180 C. for 1 hour under nitrogen. The reaction mixture is cooled stirred with ice water and the solid substance is suction filtered. The product is washed with water and diethylether and dried at 100 C. Yield: 1.6 g (54% of theory) Melting point: 176-181 C. Rf value: 0.11 (Silica gel; cyclohexane/ethyl acetate=2:8)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Karl Thomae GmbH; US5681841; (1997); A;,
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