Application of 581065-95-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 581065-95-4, name is tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
00345] tert- butyl 2-((2-(2,6-dioxopiperidin-3-yl)-l,3-dioxoisoindolin-4-yl)oxy)acetate (0775) (0.06rng, 0.13mmol) was dissolved in 1 ml. TFA. The solution was stirred at room temperature for 2 hours. Then the mixture was concentrated under reduced pressure to afford solid product, which was used in the following synthesis without further purification. Then the product from last step (0.043g, 0.13mmol) was mixed with HATH (0.099g, 0.26mmol) in 2mL DMF with the presence of EtsN (9luL, G.65mrnol). The mixture was stirred for lOmin before amino PEG-4-i-butyl ester (0.042g, O.lSmmol) was added. The reaction was stirred at room temperature for 5 hours. The mixture was next subjected to direct preparative HPLC purification to afford 97mg product (>100%) LCMS (ESI) m/z 580.22 (show as free acid instead of t-butyl ester) [(M+H)+; calcd for C^TTfiNsOii : 636.28]
The synthetic route of tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BUHRLAGE, Sara; ANDERSON, Kenneth C.; HIDESHIMA, Teru; GRAY, Nathanael S.; LIU, Xiaoxi; (137 pag.)WO2019/118728; (2019); A1;,
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