In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40876-98-0 as follows. Computed Properties of C8H11NaO5
Step 1: 6-hydroxypyrimidine-4-carboxylic acid; 63.5 g (287 mmol) sodium diethyl-oxalacetate and 30.2 g (287 mmol) formamidine acetate were added to 24.1 g (0.597 mol) NaOH in 3.6 L water. The mixture was stirred overnight at RT. Then activated charcoal was added and the mixture was refluxed for 1 h. It was filtered while hot and after cooling acidified with aqueous HCl. The solution was concentrated to dryness by rotary evaporation. The residue contained the desired product and was used in the next step without any further purification.Yield: 83.0 g
According to the analysis of related databases, 40876-98-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Boehringer Ingelheim International GmbH; US2011/172218; (2011); A1;,
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