Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39149-80-9, name is tert-Butyl 2-bromopropanoate, This compound has unique chemical properties. The synthetic route is as follows., name: tert-Butyl 2-bromopropanoate
CS2CO3 (622mg, l.9lmmol) was added to a stirred mixture of tert- butyl 3-(5,6- dimethoxythieno[3,2-b]pyridin-2-yl)-3-oxopropanoate (322mg, 0.954mmol) in DMF (3mL) at 25C. A mixture of fer/-butyl 2-bromopropanoate (2l0mg, l.OOmmol) in DMF (lmL) was added dropwise to the reaction mixture. The reaction mixture was stirred at RT for 5 hours. Additional /er/-butyl 2-bromopropanoate (63mg, 0.030mmol) was added, and the reaction mixture was stirred for 1 hour. Additional /er/-butyl 2-bromopropanoate (63mg, 0.030mmol) was added, and the reaction mixture was stirred overnight. The reaction mixture was diluted with isopropyl acetate (75mL) and sodium citrate (10% w/v in H20, 40mL). The layers were separated, and the aqueous layer was extracted with additional isopropyl acetate (40mL). The organic layers were combined, washed with brine, dried over anhydrous Na^SCri. filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (eluting EtOAC in Hex) to afford di-/er/-butyl 2-(5,6-dimethoxythieno[3,2-b]pyridine-2- carbonyl)-3-methylsuccinate. LCMS (C23H32NO7S) (ES, m/z): 466 [M+H]+.
According to the analysis of related databases, 39149-80-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ALTMAN, Michael, D.; CASH, Brandon, D.; CUMMING, Jared, N.; DEMONG, Duane, E.; HAIDLE, Andrew, M.; JEWELL, James, P.; LARSEN, Matthew, A.; LU, Min; OTTE, Ryan, D.; TAOKA, Brandon, M.; TROTTER, Benjamin Wesley; TRUONG, Quang, T.; (97 pag.)WO2019/195063; (2019); A1;,
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