Related Products of 581065-95-4,Some common heterocyclic compound, 581065-95-4, name is tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, molecular formula is C15H31NO6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 2-{3-[(2-{5-[(3a5,45,6aR)-2-oxo-hexahydro- 1 H-thieno[3,4-d]i midazolidin-4- yl]pentanamido}ethyl)carbamoyl]-5-[3, 5-bis(carboxymethoxy)phenyl]phenoxy}acetic acid(Preparation 5, 20.0 mg, 29.0 pmol) dissolved in DMF (500 pL) was added HATU (44.0 mg,116 pmol) and DIPEA (40.5 pL, 232 pmol). After 1 minute tert-butyl 1-amino-3,6,9,12- tetraoxapentadecan-15-oate (35.0 pL, 116 pmol) was added and the reaction was stirred at room temperature under nitrogen for 3 hours. The reaction was concentrated in vacuo and purified using reverse phase column chromatography (Biotage SP1, 4 g, 0-18 column, elutingwith 5-40% MeCN in water with 0.1% NH3) to afford the title compound as a colourless oil (30.9 mg, 67%).LCMS Method B: Rt = 2.96 mins, ES MS mlz 599.7 [M+H]
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, its application will become more common.
Reference:
Patent; CENTAURI THERAPEUTICS LIMITED; PICKFORD, Christopher; WATSON, Christine; GLOSSOP, Melanie; (189 pag.)WO2017/60729; (2017); A1;,
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