In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36692-49-6 as follows. Product Details of 36692-49-6
A mixture of methyl 3,4-diaminobenzoate (8, 830 mg, 5 mmol) and 4-methoxy benzaldehyde (9a, 680 mg, 5 mmol) in ethanol (25 mL) was heated with an aqueous solution of sodium pyrosulfite (1.42 g, 1.5 mmol, 5 mL) and then refluxed for 4-6 h, until TLC indicated that the reaction was complete. The ethanol was evaporated under vacuum and the residue was dissolved in CHCl3 (2 * 15 mL) and washed with water. The combined organic phases were dried over anhydrous Na2SO4, and the solvent was removed under vacuum and purified by column chromatography MeOH-CH2Cl2 (0.5:9.5) to obtain the pure product 10a as a white solid (952 mg, 68%); mp: 231-234 C; 1H NMR (500 MHz, CDCl3): delta 8.28 (s, 1H), 8.12 (d, J = 9.1 Hz, 2H), 7.92 (d, J = 9.0 Hz, 1H), 7.12 (d, J = 8.3 Hz, 1H), 6.98 (d, J = 8.3 Hz, 2H), 3.94 (s, 3H), 3.85 (s, 3H); MS (ESI): m/z 283 [M + H]+.
According to the analysis of related databases, 36692-49-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kamal, Ahmed; Nagaseshadri; Nayak, V. Lakshma; Srinivasulu, Vunnam; Sathish, Manda; Kapure, Jeevak Sopanrao; Suresh Reddy; Bioorganic Chemistry; vol. 63; (2015); p. 72 – 84;,
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