Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50624-94-7, name is tert-Butyl ethyl oxalate, A new synthetic method of this compound is introduced below., SDS of cas: 50624-94-7
Isopropylmagnesium chloride (2M in THF, 6.0 ml, 12 mmol) was added dropwise to a solution of bis(2-dimethylaminoethyl)ether (1.92 g, 12.0 mmol) in THF (50 ml) at 0 C and stirred for 15 minutes. 3-Iodobenzonitrile (2.29 g, 10.0 mmol) was added to the reaction mixture and stirred at room temperature for 20 minutes. The resulting reaction solution was added dropwise to tert-butyl ethyl oxalate (J. Org. Chem, 1996, 61, 4530) (1.92 g, 11.0 mmol) in THF (50 ml) at at -10 C and warmed to room temperature for 2 hours. The reaction was quenched with saturated NH4Cl solution (50 ml), extracted with Et2O (100 ml x 2), washed with brine, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by column chromatography on silica (EtOAc/Hexanes 10/90-30/70) to give tert- butyl 2-(3-cyanophenyl)-2-oxoacetate (892 mg, 39 %).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; EURO-CELTIQUE S.A.; SHIONOGI & CO., LTD.; WO2008/150447; (2008); A1;,
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