Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 108928-00-3, name is Ethyl 2,4-difluorobenzoate, A new synthetic method of this compound is introduced below., name: Ethyl 2,4-difluorobenzoate
The ethyl ester (3a) (3.8 g) was dissolved in fuming nitric acid (3 ml) and concentrated sulfuric acid (3 ml) at 0 C. and stirred for 2.5 hours. Thereafter, the reaction mixture was diluted with water (10 ml) and extracted with dichloromethane (200 ml). The organic phase was washed with a saturated solution of sodium chloride, dried over magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography (silica gel, hexane:acetic acid ethyl ester: 6:1) and resulted in the desired product (3.96 g).1H NMR (300 MHz, CDCl3): delta: 8.70 (m, 1H), 7.05 (m, 1H), 4.36 (q, 2H), 1.35 (t, 3H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Morphochem Aktiengesellschaft Fur Kombinatorische Chemie; US2010/324030; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics