Reference of 40061-54-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40061-54-9 as follows.
Step 4. DBU (4.1 g, 26.9 mmol, 1.2 eq) was added to a mixture of 4-(methylamino)-2-(methylthio)-pyrimidine-5-carbaldehyde (4.1 g, 22.4 mmol, 1.0 eq) and ethyl 2-(2-chlorophenyl)acetate (5.4 g, 26.9 mmol, 1.2 eq) at RT. The resulting mixture was then stirred at room temperature for 1 h, followed by addition of water and extraction with EtOAc. The combined organic layers were dried and concentrated to afford 6-(2-chlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (5.0 g, 70percent in yield).
According to the analysis of related databases, 40061-54-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Taunton, JR., John William; Brameld, Kenneth Albert; Goldstein, David Michael; Mcfarland, Jesse; Krishnan, Shyam; Choy, Jonathan; US2014/323464; (2014); A1;,
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