In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13195-64-7 as follows. HPLC of Formula: C9H16O4
General procedure: At room temperature, to a solution of nitroalkenes 2 (0.2 mmol) and chiral catalyst Q4 or QD4 in THF was added dimethyl malonate 3 (68 muL, 0.3 mmol). The resulting mixture was purified by flash chromatography when 2 was consumed through a TLC analysis to afford the product 4 or 5.
According to the analysis of related databases, 13195-64-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Li, Fei; Li, Ying-Zi; Jia, Zhen-Shan; Xu, Ming-Hua; Tian, Ping; Lin, Guo-Qiang; Tetrahedron; vol. 67; 52; (2011); p. 10186 – 10194;,
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