These common heterocyclic compound, 2318-25-4, name is Ethyl 3-ethoxy-3-iminopropionate hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H14ClNO3
A solution of 1, 2-phenylenediamine (1.0 equivalent) and ethyl 3- ETHOXY-3-IMINOPROPANOATE hydrochloride (1.3 equivalents) in ethanol was stirred at 90 C overnight. The reaction was cooled to room temperature and the solvent was removed in vacuo. Water and CH2CI2 were added to the residue. The organic layer was separated, dried over NA2SO4 and the solvent removed. The solid recovered was used without purification. LC/MS M/Z 205.2 (MH+), RIF 1. 44 minutes.
The synthetic route of Ethyl 3-ethoxy-3-iminopropionate hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHIRON CORPORATION; WO2004/18419; (2004); A2;,
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