Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35120-18-4, name is Ethyl 1-bromocyclobutanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., category: esters-buliding-blocks
General procedure: A mixture of 8a-8j (10 mmol), 15a-15d (11 mmol) and K2CO3 (4.15 g, 30 mmol) in DMF (60 mL) was stirred at room temperature (for 15a-15b) or slightly elevated temperatures (35 C for 15d and 45 C for 15c) until the reaction completed as indicated by TLC analysis (typically within 12h). On cooling (if necessary), the reaction mixture was poured into ice-water (200 mL) and the resulting mixture was extracted with CH2Cl2 (100 mL 3). The combined extracts were washed with 5% brine (100 mL 5), dried (Na2SO4) and evaporated on a rotary evaporator to afford the crude product as a residue, which was purified by column chromatography followed by trituration with EtOAc/n-hexane (if the product was solid) to yield the pure product 9a-9q.
According to the analysis of related databases, 35120-18-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Zhang, Xiansheng; Wu, Jingwei; Liu, Wei; Liu, Yuqiang; Xie, Yafei; Shang, Qian; Zhou, Zhixing; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Medicinal Chemistry; vol. 13; 3; (2017); p. 260 – 281;,
Ester – Wikipedia,
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