Related Products of 27741-65-7, The chemical industry reduces the impact on the environment during synthesis 27741-65-7, name is Ethyl 2-cyclobutylideneacetate, I believe this compound will play a more active role in future production and life.
[00269] Step 1 : Ethyl 2-cyclobutylideneacetate (408.9 mg, 2.917 mmol) was dissolved in THF (14.6 mL, 0.2 M). The solution was degassed with N2, and treated with copper (I) iodide (61 1.1 mg, 3.209 mmol). This was cooled to 0 C and treated with chlorotrimethylsilane (405.8 mu, 3.209 mmol). The mixture was stirred at 0 C for 10 minutes and then treated with ethylmagnesium bromide (2917 mu, 2.917 mmol). This was stirred at 0 C for 1 hour. The mixture was quenched with water, and the organics were extracted with Et20 twice, washed with brine and dried with Na2S04. This was then concentrated down to give ethyl 2-(l-ethylcyclobutyl)acetate (0.2675 g, 53.8%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-cyclobutylideneacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; BLAKE, James, F.; COOK, Adam; GAUDINO, John; GUNAWARDANA, Indrani, W.; HICKEN, Erik, James; HUNT, Kevin, W.; LYON, Michael; METCALF, Andrew, T.; MOHR, Peter, J.; MORENO, David, A.; NEWHOUSE, Brad; REN, Li; SCHWARZ, Jacob; CHEN, Huifen; GAZZARD, Lewis; SCHMIDT, Jane; DO, Steve; WO2015/103137; (2015); A1;,
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