Adding a certain compound to certain chemical reactions, such as: 14273-90-6, name is Methyl 6-bromohexanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14273-90-6, Recommanded Product: 14273-90-6
6- (4-CHLORO-PHENYLSULFANYL)-HEXANOIC acid methyl ester (28b). To a solution of 6-bromohexanoic acid methyl ester (2.1 g, 10 mmol), triethylamine (1.6 mL, 11 mmol) and TERT-BUTYLAMMONIUM iodide (200 mg, 0.54 mmol) in freshly distilled THF (30 mL) was added 4-chlorothiophenol (1.45 g, 10 mmol) under an atmosphere of argon. The mixture was stirred at reflux for 2 hours after which it was concentrated under reduced pressure. The oil was dissolved in ethyl acetate (100 mL) and then washed successively with saturated aqueous sodium hydrogen carbonate (50 mL), distilled water (50 ML) and brine (50 mL). The organic layer was then dried over anhydrous MGS04, filtered and concentrated under reduced pressure to give an yellow oil that was purified by flash chromatography (1: 9 diethyl ether: 40-60 °C petroleum ether). The title compound was obtained as a colourless oil (2.5 g, 93percent).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 6-bromohexanoate, and friends who are interested can also refer to it.
Reference:
Patent; QUEEN MARY & WESTFIELD COLLEGE; UNIVERSITY COLLEGE LONDON; BARTS AND THE LONDON NHS TRUST; WO2004/46094; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics