Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-02-8, name is Ethyl 4-(trifluoromethyl)benzoate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H9F3O2
First access to the microchannel reactor15 minutes of nitrogen replacement system air,Under full nitrogen protection conditions,Cool down between -40 and -30 C and start adding110 g (0.5 mol, 99%)Ethyl p-trifluoromethylbenzoate and 500a mixture of milliliters of methyl tert-butyl ether,At the same time, 0.183 liters (0.55 mol, 3 mol/L) were added dropwise.Butyl lithium solution,The reaction solution all enters the low temperature collector to obtain the compound (III);Re-use the metering pump to compound (III) and 66.1 g(0.6 mol, 99%) methyl methanesulfonate remained inBetween -40 and -30 C,Drip through the microchannel reactor for 2 hours,Sampling analysis did not detect ethyl trifluoromethylbenzoate, and the reaction solution was slowly added dropwise in ice water between 0-5 C under nitrogen protection conditions.The solvent was removed by distillation under reduced pressure to give a yellow solid;Confirmed by nuclear magnetic resonance,Target productEthyl 2-methylsulfonyl-4-trifluoromethylbenzoateThe amount of 146.5 grams,97% content,The yield was 96%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 583-02-8.
Reference:
Patent; Papanna (Beijing) Technology Co., Ltd.; Xing Wenlong; Fu Renji; (7 pag.)CN109705005; (2019); A;,
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