Application of 35120-18-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35120-18-4 as follows.
Na2S?9H2O (182mg, 0.75mmol) was added to a solution of compound 5-b (180mg, 0.5mmol) in DMF (2mL).The mixture was reacted in a microwave at 130h for 1h, cooled to room temperature, 1-bromo-cyclobutanoic acid ethylester (155mg, 0.75mmol) was added, the mixture was stirred at 50h for 2hrs. The mixture was cooled to room temperature,followed by adding ice water (20mL), being extracted with EA (50mL). The organic phases were combined, dried overanhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica preparativeplate (PE:EA = 1:1) to give white solid 24-a (89 mg, yield 40%). LC-MS (ESI): m/z = 439 [M+H]+.
According to the analysis of related databases, 35120-18-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Yingli Pharmaceutical Co. Ltd.; XU, Zusheng; ZHANG, Nong; SUN, Qingrui; WU, Tianzhi; (104 pag.)EP3275867; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics