Application of

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3618-04-0, name is trans-Ethyl 4-hydroxycyclohexanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of trans-Ethyl 4-hydroxycyclohexanecarboxylate

Intermediate 30: m-Ethyl 4-[[2-[5-[(2,4<5-trifluorophenvDapi-ino]-1.3,4-oxadiazol-2- yll -3H-benzoimidazol-5-yll oxyl cyclohexane-l-carboxylate; i) Ethyl 4-(4-amino-3-nitro-phenoxy)cvclohexane-l-earboxylate; Diisopropyl azodicarboxylate (1.72 mL, 8.71 mmol) was added in one portion to a stirred solution of ethyl 4-hydroxycyclohexanecarboxylate (1.0 g, 5.8 mmol), 4-amino-3- nitrophenol (2.69 g, 17.4 mmol) and triphenylphoshine (2.29 g, 8.71 mmol) in THF (40 mL) under an argon atmosphere. The reaction mixture was stirred at ambient temperature for 16 h and then EtOAc (150 mL) and water (150 niL) were added. The layers were separated and the organic layer was washed with a IM aqueous solution of HCl (150 mL), then a IM aqueous solution of sodium hydroxide (150 mL) and then brine (150 mL). The organic layer was dried (MgSO4), filtered and concentrated in vacuo to leave a dark brown solid. This solid was purified by column chromatography, eluting with a gradient of 30 to 40percent EtOAc in isohexane, to give the title compound as an impure orange oil (1.15 g, 64percent), that was used with no further purification; MS m/e MH+ 474.

According to the analysis of related databases, 3618-04-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/141517; (2007); A1;,
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