Reference of 23680-40-2,Some common heterocyclic compound, 23680-40-2, name is Methyl 3-bromopropiolate, molecular formula is C4H3BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 142Cmethyl 2-bromo-5-(diisopentylcarbamoyl)pyrazolo[1 ,5-a]pyridine-3-carboxylateA suspension of /V-aminopyridinium 2,4-(dinitro)phenolate (10 g, 21.67 mmol), methyl 3- bromopropiolate (3.12 ml, 26.0 mmol) and potassium carbonate (5.99 g, 43.3 mmol) in degassed DMF (75 ml) was stirred at 0 C for 5 minutes and at 22 C for 18h. The mixture was diluted with ethyl acetate (100 mL) and washed with water (3 x 25 mL), brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography on silica gel (120g, 0% to 100% ethyl acetate/hexanes over 19 min). to provide methyl 2-bromo-5-(diisopentylcarbamoyl)pyrazolo[1 ,5- a]pyridine-3-carboxylate (0.52 g, 1.186 mmol, 5.47 % yield). LCMS m/z 438.4, 440.1 (M + H)+.
The synthetic route of 23680-40-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITE DE MONTREAL; BOUVIER, Michel; MARINIER, Anne; RUEL, Rejean; RENE , Patricia; CHANTIGNY, Yves; DAGNEAU, Philippe; GINGRAS, Stephane; WO2012/100342; (2012); A1;,
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