Related Products of 107045-28-3, A common heterocyclic compound, 107045-28-3, name is tert-Butyl 4-(aminomethyl)benzoate, molecular formula is C12H17NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 2-(2,6-dioxopiperidin-3 -yl)-4-fluoroi soindoline- 1,3 -dione (2-1,200 mg, 0.724 mmol, 1 equiv) inNMP (3.6 mL, 0.2 M)was added DIPEA (525 jiL, 1.45 mmol,2 equiv) and tert-butyl 4-(aminomethyl)benzoate (165 mg, 0.796 mmol, 1.1 equiv). The reactionmixture was heated to 90 C overnight and then cooled to room temperature. EtOAc (50 mL)was added and the organic layer was washed with water (30 mL) and brine (3 x 30 mL), driedover Na2504, filtered, and concentrated in vacuo. The residue was purified by flash column
The synthetic route of 107045-28-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; BUCKLEY, Dennis; ISHOEY, Mette; WINTER, Georg; (195 pag.)WO2018/98280; (2018); A1;,
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