These common heterocyclic compound, 135484-83-2, name is Methyl 2-amino-4-bromobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H8BrNO2
B. Ethyl-2-Bromo-3-benzenepropanoate To a solution of compound A (18 g, 79 mmol) and dimethylformamide (55 mg, 0.75 mmol) in dichloromethane (160 mL) cooled to 5 C. was added a solution of oxalyl chloride (80 mL, 2M in dichloromethane). After stirring for thirty minutes at 5 C., the solution was warmed to room temperature and stirred for an additional two hours. Ethanol (100 mL, absolute) was added slowly to the solution and after 15 minutes, the mixture was heated to reflux and held there for two hours. The ethanol was removed by distillation and the desired product was isolated by vacuum distillation (107-115 C. at 0.5 mm Hg) as a colorless oil (12.63 g, 49 mmol, 62%).
The synthetic route of Methyl 2-amino-4-bromobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; E. R. Squibb & Sons, Inc.; US5225408; (1993); A;,
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