Application of 99974-66-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99974-66-0 name is Diethyl 3-hydroxycyclobutane-1,1-dicarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
a) Diethyl 3-[(methylsulfonyl)oxy]-1,1-cyclobutanedicarboxylate A solution of diethyl 3-hydroxy-1,1-cyclobutanedicarboxylate (0.268 g, 0.00116 mol) in pyridine (7 mL) was cooled to 0 C. Methanesulfonyl chloride (0.11 mL, 0.160 g, 0.00140 mol) was added dropwise, keeping the temperature below 2 C. The mixture was stirred for four hours, and then poured into ice water (20 mL) and extracted with ethyl ether (2*10 mL). The combined organic layers were washed with water (3*10 mL) and brine (10 mL). The organic layer was dried over magnesium sulfate and the solvent was removed in vacuo to give diethyl 3-[(methylsulfonyl)oxy]-1,1-cyclobutanedicarboxylate (0.302 g, 0.00102 mol) as a yellow oil.: 1H NMR (CDCl3, 400 MHz) 5.08-5.11 (m, 1H), 4.23 (q, 4H), 3.01 (s, 3H), 2.98-3.03 (m, 2H), 2.81-2.86 (m, 2H), 1.27 (t, 6H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl 3-hydroxycyclobutane-1,1-dicarboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Abbott Laboratories; US6921763; (2005); B2;,
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