Related Products of 89-91-8,Some common heterocyclic compound, 89-91-8, name is Methyl 2,2-dimethoxyacetate, molecular formula is C5H10O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
According to a general procedure for formation of a Weinreb intermediate,36 a vigorously stirred slurry of methyl dimethoxyacetate (4, 200 ^iL, 1.64 mmol) and N, O-dimethylhydroxylamine hydrochloride (201 mg, 2.05 mmol) in THF (2.4 mL) under argon was treated dropwise with isopropylmagnesium bromide (2.05 mL, 4.10 mmol, 2 M solution in THF) at -20 C. The resulting heterogeneous reaction mixture was stirred for 1.5 h at -20 C under argon. The reaction mixture was quenched with saturated aqueous NH4C1 and H20 (1 : 1). After extraction with ether (3 x 50 mL), the combined organic extract was washed (brine), dried (Na2S04) and concentrated under vacuum at room temperature. The ? NMR spectrum of the crude product showed unreacted 4 and signals consistent with those reported for l,l-dimethoxy-3-methylbutan-2-one (A).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2,2-dimethoxyacetate, its application will become more common.
Reference:
Patent; NORTH CAROLINA STATE UNIVERSITY; LINDSEY, Jonathan S.; MASS, Olga; WO2013/62670; (2013); A2;,
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