Related Products of 653-92-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 653-92-9 as follows.
2-bromo-4-fluoro-1-nitrobenzene(185.16mg, 0.842mmol) to was added Pd 2 dba 3 (23.12mg, 0.025mmol) and copperpowder a (271mg, 4.26mmol). Dimethyl sulfoxide (2.3 ml) and methyl2-bromo-4-fluorobenzoate (0.122ml, 0.842mmol) was added and the mixture wasstirred vigorously for 2 hours at 100 C. The mixture was cooled to roomtemperature, diluted with ethyl acetate (20 ml), and filtered. The filtrate waswashed with water, dried (anhydrous Na 2 SO 4), and concentrated to give ayellow oil (279.8mg). It was used in the preparation of Example 38b withoutpurification this oil.
According to the analysis of related databases, 653-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT LABORATORIES; ENANTA PHARMACEUTICALS INCORPORATED; KU, YIYIN; MCDANIEL, KEITH F; CHEN, HUI-JU; SHANLEY, JASON P; KEMPF, DALE J; GRAMPOVNIK, DAVID J; SUN, YING; LIU, DONG; GAI, YONGHUA; OR, YAT SUN; WAGAW, SEBLE H; ENGSTROM, KEN; GRIEME, TIM; (87 pag.)JP5902123; (2016); B2;,
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